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The severity of these and other adverse reactions (e. g. , rage, violent hostility, hallucinations), and their increased frequency in the elderly, has led to curtailed or suspended use of triazolam in some countries (UK).
Activation of intramural mechanoreceptors induces a neurally mediated ascending reflex contraction (red in A) and descending relaxation (blue) whereby the intraluminal bolus is moved in the anal direction. Hydrophilic colloids or bulk gels (B) comprise insoluble and nonabsorbable carbohydrate substances that expand on taking up water in the bowel.

 

Apart from poor compliance, the same problem may occur when the total daily dose is divided into three individual doses (tid) and the first dose is taken at breakfast, the second at lunch, and the third at supper. Under this condition, the nocturnal dosing interval will be twice the diurnal one.
Vegetable fibers in the diet act in this manner. They consist of the indigestible plant cell walls containing homoglycans that are resistant to digestive enzymes, e. g. , cellulose (1 4?-linked glucose molecules vs. 1 4? glucoside bond in starch, p. 153). Bran, a grain milling waste product, and linseed (flaxseed) are both rich in cellulose.

 

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