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In contrast, desipramine produces psychomotor activation. Imipramine occupies an intermediate position. It should be noted that, in the organism, biotransformation of imipramine leads to desipramine (N-desmethylimipramine). Likewise, the desmethyl derivative of amitriptyline (nortriptyline) is less dampening.
The relative density of this barrier depends on the electrical charge of molecules that attempt to permeate it. Apart from glomerular filtration (B), drugs present in blood may pass into urine by active secretion. Certain cations and anions are secreted by the epithelium of the proximal tubules into the tubular fluid via special, energyconsuming transport systems. |
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