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Stone formation may recur after cessation of successful therapy. Compared with surgical treatment, drug therapy plays a subordinate role. UCDA may also be useful in primary biliary cirrhosis. Choleretics are supposed to stimulate production and secretion of dilute bile fluid. This principle has little therapeutic significance.
Depending on the substance, release of penicillin from the depot occurs over a variable interval. Although very well tolerated, penicillin G has disadvantages (A) that limit its therapeutic usefulness: (1) It is inactivated by gastric acid, which cleaves the ?-lactam ring, necessitating parenteral administration.

 

The risk of a rebound decrease in sleep propensity after drug withdrawal may be avoided by tapering off the dose over 2 to 3 wk. With any hypnotic, the risk of suicidal overdosage cannot be ignored.
Fenestrated endothelia are found in the capillaries of the gut and endocrine glands. In the central nervous system (brain and spinal cord), capillary endothelia lack pores and there is little transcytotic activity. In order to cross the blood-brain barrier, drugs must diffuse transcellularly, i.e., penetrate the luminal and basal membrane of endothelial cells.

 

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